A different view on the skin microbiome
The connection between the skin barrier, innate immunity and microbiome
March 1, 2018 - 3 p.m. to 6 p.m.
UPTEC, Rua Alfredo Allen, n.º455/461 4200-135 Porto
Nava Dayan Ph.D. Dr. Nava Dayan LLC
It is long acknowledged that the skin serves as a key organ of biological immunity beyond being a physical shield and that its communication with the environment plays a role in human overall health, mood, and ability to cope with stress. Elements of skin’s innate immunity shape the nature of the body’s acquired humoral immunity based on environmental signals collected from birth to late in life.
Advanced genomic sequencing techniques have given rise in recent years to new findings about the human skin microbiome. These findings identify a profound difference between the gut and skin microbiomes and confirm population variability depending on skin site and condition. Additional recent research utilizing biota staining techniques reveal a potential cycle of diversity in skin biota metabolic paths.
The scalp is unique among skin areas with relatively high follicular density and an elevated rate of sebum secretion. The protected dark and warm environment on the scalp surface provides a welcoming ground to population of microorganism that may be different from those present on other skin areas. Scalp skin is heavily populated with sebaceous glands, which produce sebum that protects hair. Therefore, scalp associated disorders involve follicular secretions imbalance and innate immunity aspects such as pH, abnormal biota population and inflammation.
Lipophilic yeast Malassezia is widely accepted to play a role in scalp disorders. However, since many of the scalp microorganisms are not culturable using culture techniques it is difficult to translate to the role of biota in scalp health. Genomic and proteomic techniques utilizing identification of biota and its secretion sequencing can give rise to better understanding of disorders and pave paths for innovation in prevention and treatment.
Nava Dayan Ph.D. Pharm has 28 years of experience in the skin care segment, and has yielded more than 150 publication credits in numerous industry-respected journals and in four books. She has been awarded the In-Cosmetics Gold Award for innovation and commensurate recognition from the NYSCC and the CRS for excellence. Dr. Dayan is the owner of Dr. Nava Dayan L.L.C, a skin science and research consultancy serving the pharmaceutical, cosmetic, and personal care industries; dermal and transdermal. Dr. Dayan advises on product feasibility in skin care, composition of R&D plans covering efficacy and toxicology; planning, execution and data interpretation into claims, formulations, delivery for improved efficacy and attenuated toxicity. Sample areas of expertise include: drug-skin interaction, bio-markers (genomics and proteomics), skin/age related sensitivities, inflammatory skin disorders, innate immunity and biota.